Department of Chemistry and Biochemistry @ Boise State University

Owen M. McDougal
Associate Professor of Chemistry and Biochemistry
President, Faculty Senate
owenmcdougal@boisestate.edu
SN 323
208-426-3964

Professional Preparation
SUNY Morrisville, Morrisville, NY Chemistry A.S. 1990
SUNY Oswego, Oswego, NY Chemistry B.S. 1992
University of Utah, Salt Lake City, UT Chemistry Ph.D. 1998

Experience and Affiliations

9/09 – present President, Faculty Senate, Boise State University, Boise, ID.
8/09 – present Associate Professor, Department of Chemistry and Biochemistry, Boise State University
6/06 – present Councilor, American Chemical Society Snake River Local Section.
6/06 – present Executive Committee, AAASPD.
6/06 – 7/09 Assistant Professor, Department of Chemistry and Biochemistry, Boise State University.
9/05 – 6/06 Second Vice President, Southern Oregon Chapter of Sigma Xi; research honor society.
5/05 – 8/05 Instructor and Fellow, in Organic and Bioorganic Chemistry, University of Utah, SLC, UT.
6/04 – 9/04 Instructor and Fellow in Organic Chemistry and Green Organic Chemistry Laboratories, University of Oregon, Eugene, OR.
9/04 - 5/05 University of Utah, Visiting Associate Professor of Chemistry, sabbatical appointment, SLC, UT.
8/03 - 9/03 Instructor and Fellow in Organic Chemistry, University of Oregon, Eugene, OR.
9/02 – 6/06 Associate Professor, Department of Chemistry, Southern Oregon University.
8/02 - 9/02 Instructor and Fellow in Organic Chemistry, University of Oregon, Eugene, OR.
9/01 – present Chemistry Division Chair and Council member, AAASPD.
6/01 - 8/01 Instructor and Fellow in Biochemistry, University of Utah, Salt Lake City, UT.
9/98 – 6/02 Assistant Professor, Department of Chemistry, Southern Oregon University, Ashland, OR.
9/92 - 5/93 Instructor and Fellow in General and Organic Chemistry, University of Utah, Salt Lake City, UT.
8/91 - 5/92 Research Fellow in Organic Chemistry, SUNY at Oswego, Oswego, NY.
6/91 - 8/91 Undergraduate Research Fellow in Organometallic Chemistry, University of Utah, SLC, UT.
6/90 - 8/90 Laboratory Technician, Galson Laboratories, East Syracuse, NY, internship position.

Teaching
My background and area of greatest interest is in the instruction of Organic Spectroscopy. In this capacity, I have worked toward a systematic approach to introduce NMR, IR, and GC-MS instrumentation and to provide students with the opportunity to become very proficient in the analysis of data acquired from this instrumentation. I have used this instrumentation for undergraduate curriculum development in both Organic Spectroscopy and Biomolecular NMR courses. I can now train students at the sophomore level the basics of organic compound structure elucidation by NMR, IR, and GC-MS. I have been fortunate to be able to offer both Advanced Biomolecular NMR Courses and Advanced Organic NMR spectroscopy courses designed to prepare students for graduate studies by presenting them material appropriate at the graduate level. I look forward to taking students from these classes and continue working with them on externally funded research projects that follow this training. I have been very successful in curriculum development with undergraduates that has been published and presented at national conferences. A recent NSF CCLI grant entitled, “OSpec Web: An Online Educational Resource to Supplement the Instruction of Organic Spectroscopy”, was recently submitted for $147,828. This grant will fund the continued development of the web site: http://ospecweb.boisestate.edu.

Research

1) Conotoxin Research
Conotoxins are small peptides that have implications in the understanding of Parkinson’s disease. Students will gain experience in synthetic peptide folding and purification by high pressure liquid chromatography (HPLC), structure elucidation using NMR derived constraints and molecular dynamics computational algorithms, experimental binding studies using surface Plasmon resonance, microcalorimetry, and spectrofluorimetry, and in silico binding studies using AutoDock.

2) Boise Technology Incorporated
Students working on this project will deal with organophosphates and analyze their hydrolysis at the interface of a biphasic system by NMR spectroscopy and UV-Vis spectroscopy. The characterization of micelle formation will be performed by 1H, 13C, and 31P NMR spectroscopy. Data analyses and interest in using NMR software are required.

3) DNA Safeguard
Students working on this project will gain access to a research team of biologists, programmers and chemists. In silico modeling of ligand to receptor interaction using the AutoDock program will be used to explore targets for experimental NMR studies. The goal of this aspect of the much larger project is to understand the mechanism of antibiotic activity.

4) OSpec Web
Students working on this project will gain extensive hands on use of NMR, IR, and GC-MS. Data acquisition, analysis, reporting, and theoretical understanding will be developed. A good understanding of computers and a quick ability to adapt to diverse software will be essential.

5) Fuel Briquettes
Students working on this project will combine sawdust with shredded office paper to produce combustible fuel briquettes. The combustion properties will be studied along with the environmental health impact of particulate matter and residual ash. Students will work with community organizations to develop ways to market the briquette technology in an effort to aid those in need of assistance in Idaho. Public demonstrations will be part of the process.

6) INBRE
a) Collagen XIa1: NMR studies and in silico binding studies
b) Methionine salvage pathway: Sample preparation, component separation, NMR and MS analysis of complex biological cell extracts. This project will involve proteomics and metabolomics.

The goal of the McDougal research projects is to provide a means for students to present their work at local, regional, and national conferences. All projects are intended to lead to peer reviewed publication and most projects have money built in to support student researchers over the summer. During the academic year, students are asked to work a minimum of 10 hours per week for research credit. Those students that have experience on a project are the first to be offered paid summer research internships in the group.

PUBLICATIONS

1) Owen M. McDougal and Richard P. Steiner, “Introduction to Organic and Biological Chemistry,” Cengage Learning, Mason, OH (2009) ISBN: 1111032300.
2) *Reed B. Jacob and Owen M. McDougal, Cellular and Molecular Life Sciences, “The M-superfamily of conotoxins: a review,” (2009) DOI:10.1007/s00018-009-0125-0.
3) *Matt Turner, *Seth Eidemiller, *Bryan Martin, *Andrew Narver, *Joshua Marshall, *Logan Zemp, Kenneth A. Cornell, J. Michael McIntosh, Owen M. McDougal, Bioorganic Medicinal Chemistry, “Structural Basis for ?-Conotoxin Potency and Selectivity,” 17(16), 5894-5899 (2009).
4) Owen M. McDougal, *Matthew W. Turner, *Andrew J. Ormond, C. Dale Poulter, Biochemistry, “Three-Dimensional Structure of Conotoxin tx3a: An m-1 Branch Peptide of the M-Superfamily,” 47, 2826-2832 (2008).
5) Coyner Graf, and Owen McDougal, The Chemical Educator, “A Practical Method for the Display of High Resolution One- and Two-Dimensional NMR Spectra on the World Wide Web,” 13, 92-95 (2008).
6) Gloria P. Corpuz, Richard B. Jacobsen, Elsie C. Jimenez, Maren Watkins, Craig Walker, Clark Colledge, James E. Garrett, Owen McDougal, Wenquin Li, William R. Gray, David R. Hillyard, Jean Rivier, J. Michael McIntosh, Lourdes J. Cruz, and Baldomero M. Olivera, Biochemistry, “Definition of the M-Conotoxin Superfamily: Characterization of Novel Peptides from Molluscivorous Conus Venoms,” 44, 8176-8186 (2005).
7) *Aaron Hart and Owen McDougal, The Chemical Educator, “Spectroscopic Data Management for the Time-Strapped Educator,” Volume 9 Issue 6 (2004) pp 374-377.
8) *Jonas Buser and Owen McDougal, The Chemical Educator, “A Pedagogical Approach to the Instruction of Organic Spectroscopy,” Volume 9 Issue 4 (2004) pp 216-219.
9) Owen McDougal and C. Dale Poulter, Biochemistry, “Three-Dimensional Structure of Mini-M Conotoxin mr3a,” 43, 425-429 (2004).
10) Owen McDougal. Chapter 17, “Biochemistry”. A web chapter to accompany, Basic Concepts of Chemistry, Seventh Edition by L. Jack Malone, John Wiley & Sons, Inc., Hoboken, NJ (2003).
11) *Seth Holstein, Richard Stanley, Owen McDougal, Journal of Chemical Innovation, “Fuel Briquettes Out of Junk Mail and Yard Wastes,” 31, No. 2, 22-28 (2001).
12) Owen McDougal, Study Guide to Accompany Introduction to General, Organic, and Biological Chemistry, First Edition by Mel Armold, Harcourt College Publishers, Orlando, FL (2000).
*Undergraduate student authors

PRESENTATIONS (2007-Oct09)

8/09 Reed B. Jacob, Kenneth A. Cornell, Owen M. McDougal, oral presentation, Finding MRSA’s kryptonite: Computational directed combatant pentapeptides, 90th Annual AAASPD meeting, San Francisco, CA.
8/09 *Aubrey Johnston, Owen M. McDougal, Peptide synthesis, cleavage, and purification, 8th Annual Idaho INBRE Conference, Pocatello, ID.
8/09 *Luke Woodbury, Owen M. McDougal, Julia Oxford, Chondroitin sulfate glycosaminoglycan binding sites within collagen type XI, 8th Annual Idaho INBRE Conference, Pocatello, ID.
8/09 *Seth Eidemiller, Ken Cornell, Owen McDougal, poster presentation, Manipulation of E. coli: A metabolomics study, 8th Annual Idaho INBRE Conference, Pocatello, ID.
8/09 *David A. Luker, *Bryan Martin, *Emily Drussel, Owen McDougal, poster presentation, Taking a slice out of NMR – A new method, 8th Annual Idaho INBRE Conference, Pocatello, ID.
8/09 *Chris Mallory, *Emily Drussel, Owen McDougal, poster presentation, a-Conotoxin E11A activity towards nicotinic acetylcholine receptors, 8th Annual Idaho INBRE Conference, Pocatello, ID.
8/09 *Andrew Narver, Owen McDougal, poster presentation, pKa Determination of a-conotoxin MII and analogs, 8th Annual Idaho INBRE Conference, Pocatello, ID.
5/09 *Bryan Martin, Michael Hill, Owen McDougal, poster presentation, What does NMR have to do with the Mixing of Oil and Water? Council on Undergraduate Research Posters on the Hill, Washington DC, VA.
4/09 *Aubrey Johnston and Owen McDougal, poster presentation, Going Green at Boise State University, Undergraduate Research Conference, Boise State University, Boise, ID.
4/09 *Reed Jacob, *Matt Walters, Ken Cornell, and Owen McDougal, poster presentation, Resistance is Not Futile: Computational Directed Design of Combatant Pentapeptides, Undergraduate Research Conference, Boise State University, Boise, ID.
4/09 *Mark Swartz and Owen McDougal, poster presentation, Affordable Alternative Energy at the Community Level, Undergraduate Research Conference, Boise State University, Boise, ID.
4/09 Owen M. McDougal, invited oral presentation, Where does all the Time Go? Idaho INBRE Research Symposium, Boise State University, Boise, ID.
4/09 Owen M. McDougal, invited oral presentation, What does NMR have to do with Undergraduate Research? Experimental Nuclear Magnetic Resonance Conference 50th Annual Meeting, Asilomar, CA.
3/09 Owen M. McDougal, poster presentation, Structural Basis for ?-Conotoxin Potency and Selectivity, Experimental Nuclear Magnetic Resonance Conference 50th Annual Meeting, Asilomar, CA.
3/09 *Seth Eidemiller, Owen McDougal, poster presentation, Model Behavior: Synthetic Conotoxin Analogs for Parkinson’s, ACS 237th Annual Meeting, Salt Lake City, UT.
3/09 *Benjamin A. Parker, Julia Coppola, Henry Charlier, Owen McDougal, Michael Hill, poster presentation, Hydrolysis of Parathion in a Liquid-Liquid Biphasic System, ACS 237th Annual Meeting, Salt Lake City, UT.
3/09 *Mark Swartz, *Angela Gomez, Owen M. McDougal, poster presentation, Alternative Energy at Home, ACS 237th Annual Meeting, Salt Lake City, UT.
3/09 *Aubrey Johnston, Michael M. McCormick, Owen M. McDougal, poster presentation, Going Green in Idaho, ACS 237th Annual Meeting, Salt Lake City, UT.
3/09 *Bryan Martin, Michael Hill, Owen McDougal, poster presentation, Distribution of p-Nitrophenol in a Model Biphasic System by SPS3RE NMR Spectroscopy, ACS 237th Annual Meeting, Salt Lake City, UT.
2/09 Owen M. McDougal, invited oral presentation Brigham Young University-Idaho, Chemistry Department seminar entitled, “Idaho INBRE Research Opportunity for Undergraduates: Peptides for Parkinson’s.”
8/08 Owen M. McDougal, oral presentation in Chemical Education symposium entitled, “Innovation in Nuclear Magnetic Resonance Spectroscopy in the Undergraduate Curriculum,” led by session chair Dr. Donald Mencer, Wilkes University. Talk entitled, “OSpecWeb: An on-line educational resource to supplement the instruction of organic spectroscopy,” ACS 236th National Meeting, Philadelphia, PA.
6/08 Owen McDougal, invited oral presentation, From Snail Venom to Therapeutics: How Conotoxins Provide Insight into Drug Design, AAASPD 89th Annual Meeting Waimea, HI.
6/08 *Matthew Turner, *Logan Zemp, Owen McDougal, Boise State University, Boise, ID, Three Dimensional Solution Structure for ?-Conotoxin MII [E11A]: Structure-Function Studies in the Development of Therapeutic Approaches for Parkinson’s Disease, AAASPD 89th Annual Meeting, Waimea, HI.
4/08 Owen McDougal, Boise State University, Boise, ID, Chemistry, Chemistry Everywhere: In You, On You, Around You, Capital Scholars Showcase of Learning, BSU Student Union Building, Boise, ID.
4/08 *Taylor Dixon, Michael Hill, and Owen McDougal, Boise State University, Boise, ID, Applications of Diffusion-Ordered NMR Spectroscopy and Slice-Selection Imaging in the Study of the Interfacial Region of a Mixed Phase Solution. The 2008 Council on Undergraduate Research, Posters on the Hill, Washington, DC.
3/08 Owen McDougal, Boise State University, Boise, ID, Energy and Poverty in Idaho, Idaho Academy of Sciences 50th Annual Meeting, College of Western Idaho, Nampa, ID.
3/08 Owen McDougal, Boise State University, Boise, ID, Deadly Snails, NMR, and the Treasure Valley, Idaho Academy of Sciences 50th Annual Meeting, College of Western Idaho, Nampa, ID.
3/08 *Seth Eidemiller and Owen McDougal, Boise State University, Boise, ID, Biomass Fuel Briquettes: Composition, Compaction and Combustion, Idaho Academy of Sciences 50th Annual Meeting, College of Western Idaho, Nampa, ID.
3/08 *Matthew Turner and Owen McDougal, Boise State University, Boise, ID, Three-Dimensional Solution Structure of Conotoxin tx3a: A m-1 Branch Peptide of the M-Superfamily. Idaho Academy of Sciences 50th Annual Meeting, College of Western Idaho, Nampa, ID.
8/07 *Andrew Ormond and Owen McDougal, Boise State University, Boise, ID, Developing Therapeutic Approaches for Parkinson’s Treatment: Analysis of ?-CTx MII Analogs. The 6th Annual INBRE Research Conference, Moscow, ID.
6/07 *Matthew Turner, *Ryan Morton, and Owen McDougal, Boise State University, Boise, ID, OSpec Web: An Online Educational Resource to Facilitate the Instruction of Organic Spectroscopy. The 88th Annual AAASPD Conference, Boise, ID.
6/07 *Blake Stanhouse, *Dana Moracco, *Paige Fetzer, *Ben Parker, and Owen McDougal, Boise State University, Boise, ID, The Three C’s of Renewable Biomass Briquettes. The 88th Annual AAASPD Conference, Boise, ID.
4/07 *Dana Moracco, *Blake Stanhouse, and Owen McDougal, Boise State University, Boise, ID, Making Use of Organic Waste: Fuel Briquette Technology for Cooking and Heating. The 4th Annual Undergraduate Research Conference, Boise, ID.
*Undergraduate student authors