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Funded Projects


STEM Education for All: Building a Vision for Sustaining Innovation and Prosperity.

Period: 9/01/09-8/31/11
Co Principle Investigator                                                                     
Funding Agency: NSF-MSP Start Partnership

  • The goal of this grant is to collect data from several sources across Idaho to address STEM concerns in the state.

“Biophysical and Biochemical of Protein Structure and Interactions.”

Period:  7/01/05-6/30/07
Project Team Leader
$150,000
Funding Agency:  Office of Research Administration, Boise State University.


“Structure/function analysis of anthracycline reduction by human carbonyl reductase.”

Period: 7/01/04-6/30/09
Magnet Principle Investigator.
My portion is for about $376,000
Funding Agency: NIH NCRR
This is a subproject of the Idaho-INBRE, NIH/NCRR P20-RR16454.


“Synthesis of doxorubicin C14 benzyl ethers and evaluation as carbonyl reductase substrates and topoisomerase II inhibitors.”

Period: 5/04 – 5/05
Co Principle Investigator
$5000 
Mountain States Tumor and Medical Research Institute


“Anthracycline Reduction by Human Liver Carbonyl Reductase: Determination of the kinetic mechanisms and substrate/inhibitor specificities”

Period:  9/01/2003-8/31/04
Principal Investigator
$70,000
Funding Agency: Subproject of NIH-BRIN Grant # P20RR16454

  • The goal of this grant is to quantitatively determine the kinetic mechanisms of anthracycline reduction by human carbonyl reductase.  Structure/function studies will be used to understand what accounts for the inhibitor and substrate specificities of the enzyme.  Another goal of this grant is to generate significant preliminary data for submission of an R01 proposal to the NIH.

“Anthracycline Specificities of Carbonyl Reductases”

Period: 7/01/2003 6/30/05
Principal Investigator
$100,000
Funding Agency: NIH/NCI 1 R15 CA102119-01

  • The goal of this grant is to identify, purify and kinetically characterize the enzymes with anthracycline reductase activities that are present in rabbit heart.

“Mechanisms of Anthracycline Pharmacokinetics and Aging”

Period: 10/1/2003-9/30/07
Co-Principle Investigator
$557,400
Funding Agency:  VA Merit Review Grant
The major goals of this project are to study the effects of aging on the activity of enzymes involved in anthracycline metabolism and transport.


“Mechanistic Studies of the Peroxisomal Multifunctional Proteins I and II”

Period:  7/01/2001-6/30/2004
Principal Investigator
$38,840
Funding Agency: Research Corporation Cottrell College Science Award No. CC5404
The goal of this grant is to understand the kinetic mechanisms of multifunctional proteins I and II, in order to gain insight into their roles in bifunctional protein deficiency.


“Inhibitor Specificities of Human Liver Carbonyl Reductase”

Period: 5/12/2003-5/11/2004
Principal Investigator
$5000
Funding Agency: Mountain States Tumor and Medical Research Institute

  • The goal of this grant is to design and test human liver carbonyl reductase inhibitor candidates.

“Anthracycline Reductases from Rabbit Heart”

Period: 7/01/2002-12/31/2003
Principal Investigator
$5000
Funding Agency: Boise State University Faculty Research Grant

  • The goal of this grant is to identify, purify and kinetically characterize the enzymes with anthracylcline reductase activities that are present in rabbit heart.  Continue the work from the grant listed below.

“Purification and Characterization of Anthracycline Reductases from Rabbit Heart.”

Period: 7/01/2001-6/30/2002
Principal Investigator
$5000
Funding Agency: Moutain States Tumor Institute/Mountain States Medical Research Institute

  • The goal of this grant is to identify, purify and kinetically characterize the enzymes with anthracylcline reductase activities that are present in rabbit heart.

“Purification and Characterization of Recombinant Human Liver Carbonyl Reductase”

Period:  7/01/2002-6/30/2003
Principal Investigator
$5000
Funding Agency: Mountain States Tumor Institute/Mountain States Medical Research Institute                            

  • The goal of this grant is to develop a recombinant expression system for human carbonyl reductase and map the substrate specificities of human carbonyl reductase for anthracyclines.

“Anthracycline Specificity of Recombinant Human Carbonyl Reductase.”

Period:  7/01/2001-6/30/2002
Principal Investigator
$5000
Funding Agency: Boise State University Faculty Research Grant                           

  • The major part of this grant was to develop an expression system for human carbonyl reductase and express, purify, and characterize the kinetics of anthracycline reduction.