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Funded Projects

STEM Education for All: Building a Vision for Sustaining Innovation and Prosperity.

Co Principle Investigator                                                                      Period: 9/01/09-8/31/11

Funding Agency: NSF-MSP Start Partnership

The goal of this grant is to collect data from several sources across Idaho to address STEM concerns in the state.

 

“Biophysical and Biochemical of Protein Structure and Interactions.”

Project Team Leader            $150,000                     Period:  7/01/05-6/30/07.

Funding Agency:  Office of Research Administration, Boise State University.

 

“Structure/function analysis of anthracycline reduction by human carbonyl reductase.”

Magnet Principle Investigator    My portion is for about $376,000        Period: 7/01/04-6/30/09.

Funding Agency: NIH NCRR

This is a subproject of the Idaho-INBRE, NIH/NCRR P20-RR16454.

 

“Synthesis of doxorubicin C14 benzyl ethers and evaluation as carbonyl reductase substrates and topoisomerase II inhibitors.”

Mountain States Tumor and Medical Research Institute.

Co Principle Investigator        $5000                         Period: 5/04 – 5/05.

 

“Anthracycline Reduction by Human Liver Carbonyl Reductase: Determination of the kinetic mechanisms and substrate/inhibitor specificities”

Principal Investigator              $70,000                       Period:  9/01/2003-8/31/04

Funding Agency: Subproject of NIH-BRIN Grant # P20RR16454

The goal of this grant is to quantitatively determine the kinetic mechanisms of anthracycline reduction by human carbonyl reductase.  Structure/function studies will be used to understand what accounts for the inhibitor and substrate specificities of the enzyme.  Another goal of this grant is to generate significant preliminary data for submission of an R01 proposal to the NIH.

 

“Anthracycline Specificities of Carbonyl Reductases”

Principal Investigator              $100,000                     Period: 7/01/2003 6/30/05

Funding Agency: NIH/NCI 1 R15 CA102119-01

The goal of this grant is to identify, purify and kinetically characterize the enzymes with anthracycline reductase activities that are present in rabbit heart.

“Mechanisms of Anthracycline Pharmacokinetics and Aging”

Co-Principle Investigator        $557,400                     Period: 10/1/2003-9/30/07

Funding Agency:  VA Merit Review Grant

The major goals of this project are to study the effects of aging on the activity of enzymes involved in anthracycline metabolism and transport.

 

“Mechanistic Studies of the Peroxisomal Multifunctional Proteins I and II”

Principal Investigator              $38,840           Period:  7/01/2001-6/30/2004

Funding Agency: Research Corporation Cottrell College Science Award No. CC5404

The goal of this grant is to understand the kinetic mechanisms of multifunctional proteins I and II, in order to gain insight into their roles in bifunctional protein deficiency.

 

“Inhibitor Specificities of Human Liver Carbonyl Reductase”

Principal Investigator              $5000              Period: 5/12/2003-5/11/2004

Funding Agency: Mountain States Tumor and Medical Research Institute

The goal of this grant is to design and test human liver carbonyl reductase inhibitor candidates.

 

“Anthracycline Reductases from Rabbit Heart”

Principal Investigator              $5000              Period: 7/01/2002-12/31/2003

Funding Agency: Boise State University Faculty Research Grant

The goal of this grant is to identify, purify and kinetically characterize the enzymes with anthracylcline reductase activities that are present in rabbit heart.  Continue the work from the grant listed below.

 

“Purification and Characterization of Anthracycline Reductases from Rabbit Heart.”

Principal Investigator              $5000              Period: 7/01/2001-6/30/2002

Funding Agency: Moutain States Tumor Institute/Mountain States Medical Research Institute

The goal of this grant is to identify, purify and kinetically characterize the enzymes with anthracylcline reductase activities that are present in rabbit heart.

 

“Purification and Characterization of Recombinant Human Liver Carbonyl Reductase”

Principal Investigator              $5000              Period:  7/01/2002-6/30/2003

Funding Agency: Mountain States Tumor Institute/Mountain States Medical Research Institute

The goal of this grant is to develop a recombinant expression system for human carbonyl reductase and map the substrate specificities of human carbonyl reductase for anthracyclines.

 

“Anthracycline Specificity of Recombinant Human Carbonyl Reductase.”

Principal Investigator              $5000              Period:  7/01/2001-6/30/2002

Funding Agency: Boise State University Faculty Research Grant

The major part of this grant was to develop an expression system for human carbonyl reductase and express, purify, and characterize the kinetics of anthracycline reduction.