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Publications and Patents


Peer Reviewed Publications

14. Berhe S., Slupe A., Luster C., Charlier, Jr., H.A., Warner D.L., Zalkow L.H., Burgess E.M., Enwerem N.M., Bakare O. (2010) Synthesis of 3-[(N-carboalkoxy)ethylamino]-indazole-dione derivatives and their biological activities on human liver carbonyl reductase. Bioorg. Med. Chem. 218(1):134-41.

13. Cusack, B.J., Gambliel, H., Musser, B., Hadjokas, N., Shadle, S., Charlier, H., Olson, R.D. (2006) “Prevention of Chronic Anthracycline Cardiotoxicity in the Adult and Aged Fischer 344 Rat by Dexrazoxane and Effects on Iron Metabolism”. Cancer Chemotherapy and Pharmacology 58(4),  517-526.

12. Slupe, A., Williams, B., Larson, C., Lee, L.M., Primbs, T., Bruesch, A.J., Bjorklund, C., Warner, D.L., Peloquin, J., Shadle, S.E., Gambliel, H.A., Cusack, B.J., Olson, R.D., and Charlier, Jr., H.A. (2005)  “Reduction of 13-Deoxydoxorubicin and Daunorubicinol Anthraquinones by Human Carbonyl Reductase.” Cardiovascular Toxicology 5(4), 365-376.

11. Olson, R.D., Gambliel, H.A., Vestal, R. E., Shadle, S.E., Charlier, Jr., H. A., Cusack, B.J. (2005) “Doxorubicin Cardiac Dysfunction: Effects on Calcium Regulatory Proteins, sarcoplasmic reticulum and Triiodothyronine”, Cardiovascular Toxicology 5:269-283.

10. Charlier, Jr., H.A., Olson, R.D., Thornock, C.M., Mercer, W.K., Olson, D.R., Broyles, T.S., Muhlestein, D.J., Larson, C.L., Cusack, B.J., and Shadle, S.E. (2005) “Investigations of calsequestrin as a target for anthracyclines: comparison of functional effects of daunorubicin, daunorubicinol, and trifluoperazine.”  Molecular Pharmacology 67(5):1505-1512.

9. Charlier, Jr., H.A., Olson, R.D., Thornock, C.M., Mercer, W.K., Olson, D.R., Broyles, T.S., Muhlestein, D.J., Larson, C.L., Cusack, B.J., and Shadle, S.E. (2005) “Investigations of calsequestrin as a target for anthracyclines: comparison of functional effects of daunorubicin, daunorubicinol, and trifluoperazine.”  Molecular Pharmacology 67(5):1505-1512.

8. Charlier, Jr., H. A., and Plapp, B. V. (2000) “Kinetic Cooperativity of Human Liver Alcohol Dehydrogenase g2.”  J. Biol. Chem., 275, 11569-11575.

7. Charlier, Jr., H. A., Chakravarthy, N., and Miziorko, H. M. (1997) “Inactivation of 3-Hydroxy-3-methylglutaryl-CoA Synthase and Other Acyl-CoA-Utilizing Enzymes by 3-Oxobutylsulfoxyl-CoA.”  Biochemistry 36, 1551-1558.

6. Misra, I., Charlier, Jr., H. A., and Miziorko, H. M.  (1995) “Avian Cytosolic 3-hydroxy-3-methylglutaryl-CoA Synthase: Evaluation of the Role of Cysteines in Reaction Chemistry.”  Biochimica et Biophysica Acta 1247,253-259.

5. Charlier, H. A., Runquist, J. A., and Miziorko, H. M.  (1994) “Evidence Supporting Catalytic Roles for Aspartate Residues in Phosphoribulokinase.”  Biochemistry 33, 9343-9350.

4. Kornelsen, K.; Eldridge, J. E.; Wang, H. H.; Charlier, H. A.; Williams, J. M.  (1992) “Infrared Study of the Metal-Insulator Transition in the Organic Superconductor k -(BEDT-TTF)2Cu[N(CN)2]Cl.”  Solid State Communications 81, 343-349.

3. Wang, H. H.; Geiser, U.; Williams, J. M.; Carlson, K. D.; Kini, A. M.; Mason, J. M.; Perry, T. J.; Charlier, H. A.; Streiby-Crouch, A. V.; Heindl, J. E.; Lathrop, M. W.; Love, B. J.; Watkins, D. M.; Yaconi, G. A.  (1992) “Phase Selectivity in the Simultaneous Synthesis of the Tc = 12.8 K (0.3 kbar) Organic Superconductor k -(BEDT-TTF) 2Cu[N(CN)2]Cl or the Semiconductor (BEDT-TTF)Cu[N(CN)2]2.”  Chemistry of Materials 4, 247-249.

2. Schirber, J. E., Overmyer, D. L., Carlson, K. D., Williams, J. M., Kini, A. M., Wang, H. H., Charlier, H. A., Love, B. J. Love, Watkins, D. M., and Yaconi, G. A.  (1991) “Pressure-temperature phase diagram, inverse isotope effect, and superconductivity in excess of 13 K in k -(BEDT-TTF) 2Cu[N(CN)2]Cl, where BEDT-TTF is bis(ethylenedithio)tetrathiafulvalene.” Physical Review B 44, 4666-4669.

1. Geiser, U.; Wang, H. H.; Carlson, K. D.; Williams, J. M.; Charlier, Jr., H. A.;  Heindl, J. E.; Yaconi, G. A.; Love, B. J.; Lathrop, M. W.; Schirber, J. E.; Overmyer, D. L.; Ren, J.; Whangbo, M. H.  (1991) “Superconductivity at 2.8 K and 1.5 kbar in k -(BEDT-TTF) 2Cu2(CN)3:  The First Organic Superconductor Containing a Polymeric Copper Cyanide Anion.”  Inorganic Chemistry 30, 2586-2588.


Patents

2. Charlier, H.A., and Ewing, C.  (2010) BIPHENYL INHIBITORS OF CARBONYL REDUCTASE. US 7,781,412 B2

1. Charlier, H.A., and Gerasimchuck, N.  (2010) CYANOOXIME INHIBITORS OF CARBONYL REDUCTASE AND METHODS OF USING SAID INHIBITORS IN TREATMENTS INVOLVING ANTHRACYCLINES. US 7,727,967 B2